Questions to Ask Your Doctor
General Questions
What type of AML do I have? What does it mean to have this variant of the disease?
Do you know how quickly it is likely to progress?
Can I enroll in a clinical trial? How would this affect the quality of my treatment?
What is the recommended treatment for my stage of AML?
If I don't have insurance coverage, what are my options?
Which center would be able to provide the best treatment for my leukemia?
Are there any other options besides a bone marrow transplant?
When should I start treatment?
If I have this treatment, what are my chances of survival?
If I have treatment, will my AML return?
What are the results of the cytogenetic testing?
What are the results of the immunophenotyping?
What can I do to lower my risk of infection during chemotherapy?
Can the leukemia spread once I am on chemotherapy?
After Induction Therapy
Are blasts present?
Do I have any infections?
What is my prognosis? Are there any lifestyle changes I can make to improve my prognosis?
Are blood counts returning to normal levels?
Has complete remission been achieved?
Why do I need more treatment after I achieve remission?
For Chemotherapy
What are the names of the drugs that will be used?
How many treatments will I need? Can I go home afterwards?
What will I feel like after my treatments? Work? Children?
What are the possible side effects of these treatments? Will my hair fall out? Will I be nauseous? Will I be exhausted? Will I get mouth sores?
Is there anything I can do to lessen the side effects?
If I am taking chemotherapy, can I eat all kinds of foods?
Will chemotherapy affect my sex life?
Will chemotherapy affect my chances of getting pregnant and having a normal baby? OR
Will chemotherapy affect my chances of fathering a child?
http://www.amlalliance.com/questions-to-ask-about-aml.html
For PapAmore', Arend 'Odee' Lenderink http://papamore.blogspot.com
Thursday, June 23, 2011
What is Non-Hospice Palliative Care?
For PapAmore', Arend 'Odee' Lenderink http://papamore.blogspot.com
Sunday, June 19, 2011
Now THAT'S (Pap)Amore!
Lol, this a good photo of how I most remember you - a permanent fixture in my mind's eye and core of my heart.
For PapAmore', Arend 'Odee' Lenderink
happy papa's day, dad ... xoxo
"Old as she was, she still missed her daddy sometimes." ~Gloria Naylor
For PapAmore', Arend 'Odee' Lenderink
Wednesday, June 15, 2011
In Older AML Patients, Decitabine Showed Survival Advantage Over Standard Therapies
CHICAGO—In a Phase 3, multicenter trial involving patients ≥65 years who were newly diagnosed with de novo or secondary acute myeloid leukemia (AML), the cytosine nucleoside analog decitabine (DAC) demonstrated an overall survival advantage over standard therapies, including physician's advice (treatment choice [TC]) of supportive care or low-dose cytarabine (AraC), according to data presented at the American Society of Clinical Oncology's 2011 Annual Meeting.
Xavier G. Thomas, MD, from the Hospital Edouard Herriot, Lyon, France, and colleagues performed a randomized, controlled, open-label trial that enrolled 485 patients with poor- or intermediate-risk cytogenetics, and ECOG PS 0–2. They were randomized to either supportive care (n=28) or 20mg/m2 AraC SQ once daily for 10 consecutive days, every 4 weeks (n=215) or DAC 20mg/m2 as a 1-hour IV infusion once daily for 5 consecutive days, every 4 weeks (n=242). The primary endpoint was overall survival (OS). Additional endpoints were complete remission rates, safety, event-free survival, and relapse-free survival.
The results showed that patients randomized to DAC had a median duration of treatment of 4.4 months versus 2.4 months for those on the TC arm. The protocol-specified final analysis with 396 (81.6%) deaths showed a statistically nonsignificant but favorable trend for increased OS for patients treated with DAC, with a median survival of 7.7 months vs. 5.0 months in the TC arm; HR: 0.85, 95% CI [0.69–1.04]; P=0.108. When censored for disease modifying therapy, there was a significant improvement in OS for patients treated with DAC, with a median survival of 8.5 months vs. 5.3 months in the TC arm; HR: 0.80, 95% CI [0.64–0.99]; P=0.044.
An updated unplanned OS analysis with 446 (92%) deaths showed the same median survival with strengthened, albeit nominal evidence of the DAC effect (P=0.037) (0.82, 95%CI [0.68–0.99]). The secondary endpoint of complete remission (CR) + complete remission in the absence of total platelet recovery (CRp) rate was 17.8% (DAC) versus 7.8% (TC) with overall response (CR + CRp + partial response) of 2.5 (P=0.001). Safety rates were consistent with the known DAC safety profile and without major differences between the treatment arms. The most frequently reported Grade 3 or 4 hematologic adverse events were thrombocytopenia, anemia, neutropenia, and febrile neutropenia.
http://www.empr.com/in-older-aml-patients-decitabine-showed-survival-advantage-over-standard-therapies/article/204601/
For PapAmore', Arend 'Odee' Lenderink
Xavier G. Thomas, MD, from the Hospital Edouard Herriot, Lyon, France, and colleagues performed a randomized, controlled, open-label trial that enrolled 485 patients with poor- or intermediate-risk cytogenetics, and ECOG PS 0–2. They were randomized to either supportive care (n=28) or 20mg/m2 AraC SQ once daily for 10 consecutive days, every 4 weeks (n=215) or DAC 20mg/m2 as a 1-hour IV infusion once daily for 5 consecutive days, every 4 weeks (n=242). The primary endpoint was overall survival (OS). Additional endpoints were complete remission rates, safety, event-free survival, and relapse-free survival.
The results showed that patients randomized to DAC had a median duration of treatment of 4.4 months versus 2.4 months for those on the TC arm. The protocol-specified final analysis with 396 (81.6%) deaths showed a statistically nonsignificant but favorable trend for increased OS for patients treated with DAC, with a median survival of 7.7 months vs. 5.0 months in the TC arm; HR: 0.85, 95% CI [0.69–1.04]; P=0.108. When censored for disease modifying therapy, there was a significant improvement in OS for patients treated with DAC, with a median survival of 8.5 months vs. 5.3 months in the TC arm; HR: 0.80, 95% CI [0.64–0.99]; P=0.044.
An updated unplanned OS analysis with 446 (92%) deaths showed the same median survival with strengthened, albeit nominal evidence of the DAC effect (P=0.037) (0.82, 95%CI [0.68–0.99]). The secondary endpoint of complete remission (CR) + complete remission in the absence of total platelet recovery (CRp) rate was 17.8% (DAC) versus 7.8% (TC) with overall response (CR + CRp + partial response) of 2.5 (P=0.001). Safety rates were consistent with the known DAC safety profile and without major differences between the treatment arms. The most frequently reported Grade 3 or 4 hematologic adverse events were thrombocytopenia, anemia, neutropenia, and febrile neutropenia.
http://www.empr.com/in-older-aml-patients-decitabine-showed-survival-advantage-over-standard-therapies/article/204601/
For PapAmore', Arend 'Odee' Lenderink
Wednesday, June 8, 2011
Tuesday, June 7, 2011
Poems in Remembrance of Fathers
What would I give to clasp his hand,
His happy face to see,
To hear his voice, and see his smile
That meant so much to me.
**
The rolling stream of life rolls on.
But still the vacant chair
Recalls the love, the voice, the smile
Of the one who once sat there.
**
Nothing can ever take away
The love a heart holds dear.
Fond memories linger every day,
Remembrance keeps him near.
Remembrance Poems for Fathers
He had a nature you could not help loving,
And a heart that was purer than gold,
And to those who knew him and loved him
His memory will never grow cold.
**
More and more each day we miss him
Friends may think the wound is healed
But they little know the sorrow
Lying within our hearts concealed
**
You’re not forgotten, father dear
Nor ever shall you be
As long as life and memory last
I shall remember thee.
**
His memory is as dear today
As in the hour he passed away.
Remembrance Poems for Fathers
The blow was great, the shock severe
We little thought his death so near
Only those that have lost can tell
The sorrow of parting without farewell
**
We often think of days gone by
When we were all together.
A shadow o’er our lives is cast,
Our loved one gone forever.
**
And have you gone, forever gone
And left us here to weep
Till we are called to follow you,
And in the grave to sleep.
Yet since you could no longer stay
To cheer us with your love,
We hope to meet you again in
The bright world above.
**
One precious to our hearts has gone,
The voice we loved is stilled;
The place made vacant in our home
Can never more be filled.
Our Father in His wisdom called
The one His love had given,
And so on earth the body lays -
His soul is safe in Heaven.
**
No one knows how much I miss you,
No one knows the bitter pain
I have suffered; since I lost you
Life has never been the same.
In my heart your memory lingers,
Sweetly tender, fond and true;
There is not a day, dear father,
That I do not think of you.
**
We think of him in silence,
No eyes can see us weep;
But still within our aching hearts,
His memory we keep.
**
Silent is the voice we loved to hear;
Too far away for sight or speech,
But not too far for thought to reach.
Sweet to remember him who once was here,
And who, though absent, is just as dear.
For PapAmore', Arend 'Odee' Lenderink
His happy face to see,
To hear his voice, and see his smile
That meant so much to me.
**
The rolling stream of life rolls on.
But still the vacant chair
Recalls the love, the voice, the smile
Of the one who once sat there.
**
Nothing can ever take away
The love a heart holds dear.
Fond memories linger every day,
Remembrance keeps him near.
Remembrance Poems for Fathers
He had a nature you could not help loving,
And a heart that was purer than gold,
And to those who knew him and loved him
His memory will never grow cold.
**
More and more each day we miss him
Friends may think the wound is healed
But they little know the sorrow
Lying within our hearts concealed
**
You’re not forgotten, father dear
Nor ever shall you be
As long as life and memory last
I shall remember thee.
**
His memory is as dear today
As in the hour he passed away.
Remembrance Poems for Fathers
The blow was great, the shock severe
We little thought his death so near
Only those that have lost can tell
The sorrow of parting without farewell
**
We often think of days gone by
When we were all together.
A shadow o’er our lives is cast,
Our loved one gone forever.
**
And have you gone, forever gone
And left us here to weep
Till we are called to follow you,
And in the grave to sleep.
Yet since you could no longer stay
To cheer us with your love,
We hope to meet you again in
The bright world above.
**
One precious to our hearts has gone,
The voice we loved is stilled;
The place made vacant in our home
Can never more be filled.
Our Father in His wisdom called
The one His love had given,
And so on earth the body lays -
His soul is safe in Heaven.
**
No one knows how much I miss you,
No one knows the bitter pain
I have suffered; since I lost you
Life has never been the same.
In my heart your memory lingers,
Sweetly tender, fond and true;
There is not a day, dear father,
That I do not think of you.
**
We think of him in silence,
No eyes can see us weep;
But still within our aching hearts,
His memory we keep.
**
Silent is the voice we loved to hear;
Too far away for sight or speech,
But not too far for thought to reach.
Sweet to remember him who once was here,
And who, though absent, is just as dear.
For PapAmore', Arend 'Odee' Lenderink
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