Tuesday, December 11, 2012

Recent Promising Treatment for Late-Stage AML (Acute Myelogenous Leukemia)

Are there any promising treatments in late-stage testing?

Yes, there are several drugs being investigated in phase II and phase III trials. We currently have a phase III trial open with a drug called rigosertib for patients who have failed prior treatment with azacitidine or decitabine, which are known as demethylating agents. The proposed mechanism of action for these drugs is that they alter gene expression profiles in the cancer cells and increase their susceptibility to death. Rigosertib is a cell cycle inhibitor and would prevent the cancer cells from growing and induce direct damage to the cancer cells, causing their death.

For PapAmore', Arend 'Odee' Lenderink 
http://papamore.blogspot.com

A Video Update on Papa's Namesake - Lil' Arend

Arend Jack Thomas Wagasky (lil' odee/papa's boy) 


For PapAmore', Arend 'Odee' Lenderink 
http://papamore.blogspot.com

Thursday, November 29, 2012

Dear Dad in Heaven

Dear Dad in Heaven, 



I sit here and i ponder how very much
I'd like to talk to you today
There are so many things
That we didn't get to say
I know how much you care for me
And how much I care for you,
And each time that I think of you
I know you'll miss me too.
An angel came and called your name
And took you by the hand and said
Your place was ready in Heaven, far above . . .

And you had to leave behind,
all though you dearly loved
You had so much to live for, you had so much to do . . .
It still seemed impossible, that God was taking you.
And though your life on earth is past,
n Heaven it starts anew
You'll live for all eternity, just as God has promised you.
And though you've walked through Heaven's gate
We are never far apart



For PapAmore', Arend 'Odee' Lenderink 

Wednesday, September 12, 2012

How to Know the End is Near


How will I know when someone is getting close to death?

Just as doctors cannot pinpoint the precise day when a baby will be born, they cannot predict the exact day or hour when you or your loved one will die. 

You might need reassurance that it is simply not always possible to know when death is near. Some illnesses, for example, make prediction difficult. However, many illnesses have a few hours or a few days when it is evident that death is close. 

The person dying usually is no longer eating or drinking, except perhaps a few sips of liquid now and again. The person may be sleepy or confused most of the time and is usually in bed. If the person is dying from cancer or a progressive failure of an organ, he or she will usually have lost a substantial amount of weight. If life support is being stopped, the physician should be able to tell you what to watch for to estimate about how long it will be before death.

Many people near death have cool hands and feet and a persistent purplish discoloration in the parts of the body resting on the bed. Many also will have uneven breathing, sometimes stopping for many seconds and other times breathing quickly. This kind of breathing and discoloration can persist for a few days or may be seen within hours of death.

Some people have some jerking motions or even seizures near death. As disturbing as it may be for you to watch this happen, your loved one will probably not be aware of it. Involuntary motions usually do not need treatment and do not cause problems for the patient. Seizures can often be treated with rectal medications to be sure that they are not distressing to the patient or family.

If the person has been taking opioids, these will be continued because stopping such medications abruptly can lead to uncomfortable symptoms. If the person is no longer able to swallow, opioids can be given by suppository, injection, skin patch, subcutaneous infusion, or IV.

Probably half of patients develop very noisy breathing near death, sometimes called a "death rattle." This is the result of physical changes and does not cause the person to feel as though she is struggling to breathe. In fact, most dying patients are not aware of this noisy breathing. However, if family or caregivers find it unnerving, the doctor or nurse can help reduce the noisy sound, either by giving medication or repositioning the dying person in bed.

http://www.growthhouse.org/mortals/mor13102.html


For PapAmore', Arend 'Odee' Lenderink

Wednesday, August 15, 2012

Sometimes God Says No



I listened to a sermon by Joel Osteen this past Sunday - he said that if we truly believe and pray in faith God will hear our calls and answer them accordingly ...

Good sermon, but just can't help but wondering ...

Why did the many prayers going out to heal you go unanswered, Papa?

I take issue with being made to feel like we didn't believe nor pray ENOUGH - because that's simply and completely not at all true.


For PapAmore', Arend 'Odee' Lenderink
http://papamore.blogspot.com